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Feeding Rhythm-Induced Hypothalamic Agouti-Related Protein Elevation via Glucocorticoids Leads to Insulin Resistance in Skeletal Muscle
https://tokushima-u.repo.nii.ac.jp/records/2010107
https://tokushima-u.repo.nii.ac.jp/records/201010754424f1f-cfc6-4bfe-b130-6a7e31ff6e85
| 名前 / ファイル | ライセンス | アクション |
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ijms_22_19_10831.pdf (3.04 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||
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| 公開日 | 2022-08-01 | |||||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.3390/ijms221910831 | |||||||||||||||||||||||
| 関連名称 | 10.3390/ijms221910831 | |||||||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Feeding Rhythm-Induced Hypothalamic Agouti-Related Protein Elevation via Glucocorticoids Leads to Insulin Resistance in Skeletal Muscle | |||||||||||||||||||||||
| 著者 |
志内, 哲也
× 志内, 哲也
WEKO
479
× オオツカ, アイリ
× 清水, 紀之× 近久, 幸子× セイ, ヒロヨシ
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| 内容記述 | Circadian phase shifts in peripheral clocks induced by changes in feeding rhythm often result in insulin resistance. However, whether the hypothalamic control system for energy metabolism is involved in the feeding rhythm-related development of insulin resistance is unknown. Here, we show the physiological significance and mechanism of the involvement of the agouti-related protein (AgRP) in evening feeding-associated alterations in insulin sensitivity. Evening feeding during the active dark period increased hypothalamic AgRP expression and skeletal muscle insulin resistance in mice. Inhibiting AgRP expression by administering an antisense oligo or a glucocorticoid receptor antagonist mitigated these effects. AgRP-producing neuron-specific glucocorticoid receptor-knockout (AgRP-GR-KO) mice had normal skeletal muscle insulin sensitivity even under evening feeding schedules. Hepatic vagotomy enhanced AgRP expression in the hypothalamus even during ad-lib feeding in wild-type mice but not in AgRP-GR-KO mice. The findings of this study indicate that feeding in the late active period may affect hypothalamic AgRP expression via glucocorticoids and induce skeletal muscle insulin resistance. | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | AgRP | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | glucocorticoid | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | feeding rhythm | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | insulin sensitivity | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | skeletal muscle | |||||||||||||||||||||||
| 書誌情報 |
en : International Journal of Molecular Sciences 巻 22, 号 19, p. 10831, 発行日 2021-10-07 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 14220067 | |||||||||||||||||||||||
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| 出版者 | MDPI | |||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||
| 権利情報 | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | |||||||||||||||||||||||
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| 識別子 | 386719 | |||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||
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Cite as
志内, 哲也, オオツカ, アイリ, 清水, 紀之, 近久, 幸子, セイ, ヒロヨシ, 2021, Feeding Rhythm-Induced Hypothalamic Agouti-Related Protein Elevation via Glucocorticoids Leads to Insulin Resistance in Skeletal Muscle: MDPI, 10831– p.
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