| Item type |
文献 / Documents(1) |
| 公開日 |
2022-08-26 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1016/j.nut.2022.111798 |
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関連名称 |
10.1016/j.nut.2022.111798 |
| 出版タイプ |
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出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
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タイトル |
Association of phase angle with muscle function and prognosis in patients with head and neck cancer undergoing chemoradiotherapy |
| タイトル別表記 |
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その他のタイトル |
Association of phase angle with muscle function and prognosis |
| 著者 |
ヤマナカ, アヤカ
(安井)山田, 苑子
フルモト, タイキ
クボ, ミユ
ハヤシ, ハルカ
キタオ, ミドリ
ワダ, キョウコ
オオマエ, ナオ
神村, 盛一郎
島田, 亜紀
佐藤, 紀
加藤, 真介
武田, 憲昭
濵田, 康弘
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| 抄録 |
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内容記述 |
Objective: We aimed to investigate the correlation of phase angle (PhA) with other parameters (e.g., muscle mass/quality/strength and physical function), assess the prognostic relevance of pre-chemoradiotherapy (CRT) PhA, and suggest a reference value of PhA in Asian patients with head and neck cancer (HNC).
Research Methods & Procedures: Ninety-six patients with HNC who underwent CRT were divided into two groups, maintained-PhA group and low-PhA group, according to the PhA 25th percentile values by sex. Pretreatment PhA was measured using direct segmental multi-frequency bioelectrical impedance analysis, and muscle quality was assessed using echo intensity in ultrasound images. Correlation of PhA with other parameters was investigated, and between-group differences with respect to adverse events, treatment interruption, and 3-year survival were assessed.
Results: PhA showed a positive correlation with isometric knee extension force (R = 0.710), handgrip strength (R = 0.649), skeletal muscle mass index (R = 0.620), and maximum gait speed (R = 0.543) (P < 0.001). PhA showed a negative correlation with echo intensity (R = −0.439) and five times sit-to-stand test (R = −0.505) (P < 0.01). The low-PhA group had a higher incidence of severe anemia (52% in low-PhA vs. 17% in maintained-PhA), aspiration (17% vs. 1%), radiotherapy interruption (17% vs. 3%), and poor 3-year survival (47% vs. 81%) than the maintained-PhA group (P < 0.05).
Conclusion: PhA was correlated with muscle mass/quality/strength, and physical function. Low PhA was associated with severe adverse events, treatment interruption, and shorter survival. These findings suggested that 4.6° for men and 4.0° for women may be useful as prognostic reference values in Asian patients with HNC. |
| キーワード |
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|
主題 |
Phase angle |
| キーワード |
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|
主題 |
Muscle strength |
| キーワード |
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|
主題 |
Muscle quality |
| キーワード |
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|
主題 |
Physical function |
| キーワード |
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主題 |
Prognosis |
| キーワード |
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主題 |
Head and neck cancer |
| 書誌情報 |
en : Nutrition
巻 103-104,
p. 111798,
発行日 2022-07-19
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
08999007 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10745727 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11535297 |
| 出版者 |
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出版者 |
Elsevier |
| 権利情報 |
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|
権利情報 |
© 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| EID |
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識別子 |
386942 |
| 言語 |
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言語 |
eng |
nut_103-104_111798.pdf (620 KB)
