| Item type |
文献 / Documents(1) |
| 公開日 |
2022-08-30 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
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|
関連識別子 |
https://doi.org/10.1093/oncolo/oyab077 |
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|
関連名称 |
10.1093/oncolo/oyab077 |
| 出版タイプ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Prevention of Pemetrexed-Induced Rash Using Low-Dose Corticosteroids : A Phase II Study |
| 著者 |
サクラダ, タクミ
軒原, 浩
コガ, タダシ
座間味, 義人
合田, 光寛
八木, 健太
濱野, 裕章
相澤, 風花
荻野, 広和
佐藤, 正大
キリノ, ヤスシ
後東, 久嗣
西岡, 安彦
石澤, 啓介
|
| 抄録 |
|
|
内容記述 |
Background: Rash eruptions are a common side-effect of pemetrexed, for which the administration of 8 mg/day of dexamethasone for 3 days from the day preceding pemetrexed administration is recommended. This study aimed to prospectively assess the effectiveness of prophylactic administration of low-dose dexamethasone for pemetrexed-induced rashes.
Methods: This single-arm, phase II study recruited patients with non-squamous non–small cell lung cancer and malignant pleural mesothelioma scheduled to receive chemotherapy including pemetrexed. Patients received 2 mg of dexamethasone daily from days 2 to 6 after chemotherapy with pemetrexed. The primary endpoint was the 3-week incidence of rash eruptions.
Results: Twenty-five patients were enrolled between September 2017 and May 2019. The incidence of rash after 3 weeks was 16.7%. Rashes erupted mainly on the upper half of the body, such as the chest and neck, and were of grades 1 and 2 in 2 patients each. No rashes of grade 3 or higher were observed, and there were no adverse events associated with additional corticosteroids.
Conclusion: Prophylactic administration of low-dose dexamethasone for 5 days from the day after pemetrexed administration resulted in a milder incidence and severity of rash. These findings may provide a standard preventative strategy for pemetrexed-induced rashes. (Trial identifier: UMIN000025666). |
| キーワード |
|
|
主題 |
Rash prevention |
| キーワード |
|
|
主題 |
low-dose dexamethasone |
| キーワード |
|
|
主題 |
pemetrexed |
| キーワード |
|
|
主題 |
non-squamous non–small cell lung cancer |
| キーワード |
|
|
主題 |
malignant pleural mesothelioma |
| 書誌情報 |
en : The Oncologist
巻 27,
号 7,
p. e554-e560,
発行日 2022-03-24
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1549490X |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
10837159 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11157189 |
| 出版者 |
|
|
出版者 |
Oxford University Press |
| 権利情報 |
|
|
権利情報 |
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| EID |
|
|
識別子 |
387316 |
| 言語 |
|
|
言語 |
eng |
oncolo_27_7_e554.pdf (220 KB)
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