| Item type |
文献 / Documents(1) |
| 公開日 |
2022-09-08 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1111/cas.15321 |
|
|
関連名称 |
10.1111/cas.15321 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Intraperitoneal administration of nanoparticles containing tocopheryl succinate prevents peritoneal dissemination |
| 著者 |
ハマ, ススム
ニシ, タカユキ
イソノ, エイタロウ
イタクラ, ショウコ
ヨシカワ, ユタカ
ニシモト, アキノリ
スズキ, サトコ
キリムラ, ナオコ
トウドウ, ヒロアキ
小暮, 健太朗
|
| 抄録 |
|
|
内容記述 |
Intraperitoneal administration of anticancer nanoparticles is a rational strategy for preventing peritoneal dissemination of colon cancer due to the prolonged retention of nanoparticles in the abdominal cavity. However, instability of nanoparticles in body fluids causes inefficient retention, reducing its anticancer effects. We have previously developed anticancer nanoparticles containing tocopheryl succinate, which showed high in vivo stability and multifunctional anticancer effects. In the present study, we have demonstrated that peritoneal dissemination derived from colon cancer was prevented by intraperitoneal administration of tocopheryl succinate nanoparticles. The biodistribution of tocopheryl succinate nanoparticles was evaluated using inductively coupled plasma mass spectroscopy and imaging analysis in mice administered quantum dot encapsulated tocopheryl succinate nanoparticles. Intraperitoneal administration of tocopheryl succinate nanoparticles showed longer retention in the abdominal cavity than by its intravenous (i.v.) administration. Moreover, due to effective biodistribution, tumor growth was prevented by intraperitoneal administration of tocopheryl succinate nanoparticles. Furthermore, the anticancer effect was attributed to the inhibition of cancer cell proliferation and improvement of the intraperitoneal microenvironment, such as decrease in the levels of vascular endothelial growth factor A, interleukin 10, and M2-like phenotype of tumor-associated macrophages. Collectively, intraperitoneal administration of tocopheryl succinate nanoparticles is expected to have multifaceted antitumor effects against colon cancer with peritoneal dissemination. |
| キーワード |
|
|
主題 |
ascites |
| キーワード |
|
|
主題 |
intraperitoneal administration |
| キーワード |
|
|
主題 |
nanoparticles |
| キーワード |
|
|
主題 |
peritoneal dissemination |
| キーワード |
|
|
主題 |
tocopheryl succinate |
| 書誌情報 |
en : Cancer Science
巻 113,
号 5,
p. 1779-1788,
発行日 2022-03-06
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13497006 |
| 出版者 |
|
|
出版者 |
Japanese Cancer Association |
| 出版者 |
|
|
出版者 |
John Wiley & Sons |
| 権利情報 |
|
|
権利情報 |
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| EID |
|
|
識別子 |
386963 |
| 言語 |
|
|
言語 |
eng |
cas_113_5_1779.pdf (1.36 MB)
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