| Item type |
文献 / Documents(1) |
| 公開日 |
2023-07-21 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1111/1348-0421.12487 |
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|
言語 |
ja |
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|
関連名称 |
10.1111/1348-0421.12487 |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
|
|
タイトル |
Dendritic cell-targeting DNA-based nasal adjuvants for protective mucosal immunity to Streptococcus pneumoniae |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
DNA adjuvants for potent mucosal immunity |
|
言語 |
en |
| 著者 |
片岡, 宏介
フクヤマ, ヨシコ
Briles, David E.
ミヤケ, タツロウ
フジハシ, コウタロウ
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
In order to develop safe vaccines for effective mucosal immunity to major pulmonary bacterial infections, one must consider appropriate vaccine antigens (Ags), delivery systems and nontoxic molecular adjuvants. Such vaccine constructs can induce Ag-specific immune responses which provide effective protection from mucosal infections. In particular, it has been shown that adjuvant-based mucosal vaccine preparations are relatively easy to construct by simply mixing the adjuvant with the bacterial Ag, and the resulting vaccine can elicit protective immunity. We have studied DNA-based nasal adjuvants targeting mucosal dendritic cells (DCs) in order to induce Ag-specific mucosal and systemic immune responses that provide essential protection against microbial pathogens which invade our mucosal surfaces. In this review, we initially introduce a plasmid encoding the cDNA of Flt3 ligand (pFL), a molecule which is a growth factor for DCs as an effective adjuvant for mucosal immunity to pneumococcal infections. Next, we discuss the potential of adding unmethylated CpG oligodeoxynucleotide together with pFL together with a pneumococcal Ag for protection from pneumococcal infections. To do this, we have used pneumococcal surface protein A as vaccine for the restoration of mucosal immunity in aging. Further, we have also used our nasal pFL adjuvant system with phosphorylcholine-keyhole limpet hemocyanin (PC-KLH) in pneumococcal vaccine development, to successfully induce complete protection from nasal carriage by Streptococcus pneumoniae. Finally, we discuss the possibility that anti-PC antibodies induced by nasal delivery of pFL plus PC-KLH may play a protective role for prevention of atherogenesis and thus block the subsequent development of cardiovascular disease. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
dendritic cells |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
DNA-based adjuvants |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
nasal vaccination |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Streptococcus pneumoniae |
| 書誌情報 |
en : Microbiology and Immunology
巻 61,
号 6,
p. 195-205,
発行日 2017-05-02
|
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
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収録物識別子 |
13480421 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00738350 |
| 出版者 |
|
|
出版者 |
Japanese Society for Bacteriology |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Japanese Society for Virology |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Japanese Society for Host Defense Research |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
John Wiley & Sons |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is the peer reviewed version of the following article: Kataoka, K., Fukuyama, Y., Briles, D.E., Miyake, T. and Fujihashi, K. (2017), Dendritic cell-targeting DNA-based nasal adjuvants for protective mucosal immunity to Streptococcus pneumoniae. Microbiol Immunol, 61: 195-205., which has been published in final form at https://doi.org/10.1111/1348-0421.12487. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wileyʼs version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. |
| EID |
|
|
識別子 |
374192 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
mi_61_6_195.pdf (1.23 MB)
