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Iontophoresis of Biological Macromolecular Drugs
https://tokushima-u.repo.nii.ac.jp/records/2010392
https://tokushima-u.repo.nii.ac.jp/records/2010392cf4131b8-bb9f-4e32-83cd-660019d5a65a
| 名前 / ファイル | ライセンス | アクション |
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pharm_14_3_525.pdf (1.07 MB)
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| アイテムタイプ | 文献 / Documents(1) | |||||||||||||||
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| 公開日 | 2022-12-21 | |||||||||||||||
| アクセス権 | ||||||||||||||||
| アクセス権 | open access | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| 出版社版DOI | ||||||||||||||||
| 関連識別子 | https://doi.org/10.3390/pharmaceutics14030525 | |||||||||||||||
| 関連名称 | 10.3390/pharmaceutics14030525 | |||||||||||||||
| 出版タイプ | ||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Iontophoresis of Biological Macromolecular Drugs | |||||||||||||||
| 著者 |
Hasan, Mahadi
× Hasan, Mahadi
× Khatun, Anowara
× 小暮, 健太朗
WEKO
1139
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| 抄録 | ||||||||||||||||
| 内容記述 | Over the last few decades, biological macromolecular drugs (e.g., peptides, proteins, and nucleic acids) have become a significant therapeutic modality for the treatment of various diseases. These drugs are considered superior to small-molecule drugs because of their high specificity and favorable safety profiles. However, such drugs are limited by their low oral bioavailability and short half-lives. Biological macromolecular drugs are typically administrated via invasive methods, e.g., intravenous or subcutaneous injections, which can be painful and induce needle phobia. Noninvasive transdermal delivery is an alternative administration route for the local and systemic delivery of biological macromolecular drugs. However, a challenge with the noninvasive transdermal delivery of biological macromolecular drugs is the outermost layer of the skin, known as the stratum corneum, which is a physical barrier that restricts the entry of extraneous macromolecules. Iontophoresis (IP) relies on the application of a low level of electricity for transdermal drug delivery, in order to facilitate the skin permeation of hydrophilic and charged molecules. The IP of several biological macromolecular drugs has recently been investigated. Herein, we review the IP-mediated noninvasive transdermal delivery of biological macromolecular drugs, their routes of skin permeation, their underlying mechanisms, and their advance applications. | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題 | biological macromolecular drugs | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題 | skin barrier | |||||||||||||||
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| 主題 | transdermal delivery | |||||||||||||||
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| 主題 | iontophoresis | |||||||||||||||
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| 主題 | low electricity | |||||||||||||||
| 書誌情報 |
en : Pharmaceutics 巻 14, 号 3, p. 525, 発行日 2022-02-26 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||
| 収録物識別子 | 19994923 | |||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | MDPI | |||||||||||||||
| 権利情報 | ||||||||||||||||
| 権利情報 | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | |||||||||||||||
| EID | ||||||||||||||||
| 識別子 | 390037 | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
