| Item type |
文献 / Documents(1) |
| 公開日 |
2023-02-07 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3390/molecules22122202 |
|
|
言語 |
ja |
|
|
関連名称 |
10.3390/molecules22122202 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Anti-Allergic Activity of Monoacylated Ascorbic Acid 2-Glucosides |
|
言語 |
en |
| 著者 |
ミウラ, カオリ
モリシタ, ユウタ
マツノ, ヒロアキ
アオタ, ユウスケ
イトウ, ヒデユキ
田井, 章博
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
2-O-α-D-Glucopyranosyl-L-ascorbic acid (AA-2G) is one of the stable ascorbic acid (AA) derivatives known as provitamin C agents. We have previously synthesized two types of monoacylated derivatives of AA-2G, 6-O-acyl-2-O-α-D-glucopyranosyl-L-ascorbic acids having a straight-acyl chain of varying length from C4 to C18 (6-sAcyl-AA-2G) and a branched-acyl chain of varying length from C6 to C16 (6-bAcyl-AA-2G) in order to improve the bioavailability of AA-2G. In this study, 6-sAcyl-AA-2G and 6-bAcyl-AA-2G per se showed the inhibitory effects on hyaluronidase activity and degranulation. 6-sAcyl-AA-2G exhibited strong inhibitory effects on hyaluronidase activity and degranulation in a concentration-dependent manner, and the inhibitory effects tended to become stronger with increasing length of the acyl chain. 2-O-α-D-Glucopyranosyl-6-O-hexadecanoyl-L-ascorbic acid (6-sPalm-AA-2G), which has a straight C16 acyl chain, was the most potent effective for inhibition of hyaluronidase activity and for inhibition of degranulation among the 6-sAcyl-AA-2G derivatives and the two isomers of 6-sPalm-AA-2G. Furthermore, percutaneous administration of 6-sPalm-AA-2G significantly inhibited IgE-mediated passive cutaneous anaphylaxis reaction in mice. These findings suggest that 6-sPalm-AA-2G will be useful for treatment of allergies. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
ascorbic acid derivatives |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
anti-allergic activity |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
degranulation |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
hyaluronidase |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
passive cutaneous anaphylaxis |
| 書誌情報 |
en : Molecules
巻 22,
号 12,
p. 2202,
発行日 2017-12-12
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14203049 |
| 出版者 |
|
|
出版者 |
MDPI |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
359257 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
molecules_22_12_2202.pdf (815 KB)
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