| Item type |
文献 / Documents(1) |
| 公開日 |
2023-02-08 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3390/membranes12080782 |
|
|
言語 |
ja |
|
|
関連名称 |
10.3390/membranes12080782 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Evaluation of the Growth-Inhibitory Spectrum of Three Types of Cyanoacrylate Nanoparticles on Gram-Positive and Gram-Negative Bacteria |
|
言語 |
en |
| 著者 |
Sarian, Fean Davisunjaya
アンドウ, カズキ
ツルミ, ショウタ
ミヤシタ, リョウヘイ
右手, 浩一
オオハマ, タケシ
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The development of novel effective antibacterial agents is crucial due to increasing antibiotic resistance in various bacteria. Poly (alkyl cyanoacrylate) nanoparticles (PACA-NPs) are promising novel antibacterial agents as they have shown antibacterial activity against several Gram-positive and Gram-negative bacteria. However, the antibacterial mechanism remains unclear. Here, we compared the antibacterial efficacy of ethyl cyanoacrylate nanoparticles (ECA-NPs), isobutyl cyanoacrylate NPs (iBCA-NPs), and ethoxyethyl cyanoacrylate NPs (EECA-NPs) using five Gram-positive and five Gram-negative bacteria. Among these resin nanoparticles, ECA-NPs showed the highest growth inhibitory effect against all the examined bacterial species, and this effect was higher against Gram-positive bacteria than Gram-negative. While iBCA-NP could inhibit the cell growth only in two Gram-positive bacteria, i.e., Bacillus subtilis and Staphylococcus aureus, it had negligible inhibitory effect against all five Gram-negative bacteria examined. Irrespective of the differences in growth inhibition induced by these three NPs, N-acetyl-L-cysteine (NAC), a well-known reactive oxygen species (ROS) scavenger, efficiently restored growth in all the bacterial strains to that similar to untreated cells. This strongly suggests that the exposure to NPs generates ROS, which mainly induces cell growth inhibition irrespective of the difference in bacterial species and cyanoacrylate NPs used. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
antibacterial agent |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cyanoacrylate nanoparticle |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
membrane damage |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
reactive oxygen species |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
stress response |
| 書誌情報 |
en : Membranes
巻 12,
号 8,
p. 782,
発行日 2022-08-15
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
20770375 |
| 出版者 |
|
|
出版者 |
MDPI |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
389314 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
memb_12_8_782.pdf (2.41 MB)
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