| Item type |
文献 / Documents(1) |
| 公開日 |
2023-01-31 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1111/joor.13414 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1111/joor.13414 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Nocebo response in dentistry : A systematic review and meta-analysis of adverse events in analgesic trials of third molar removal |
|
言語 |
en |
| 著者 |
渡邊, 毅
Sieg, Mette
Lunde, Sigrid Juhl
Persson, Mads
Taneja, Pankaj
Baad-Hansen, Lene
Pigg, Maria
Vase, Lene
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: The nocebo response refers to the phenomenon where non-specific factors, including negative verbal suggestion and treatment expectations, cause adverse events (AE) following a placebo treatment. Non-specific factors are also likely to influence AE occurrence following administration of active pharmacological treatments.
Objective: This meta-analysis aimed to estimate the nocebo response in dentistry by assessing the AEs prevalence in placebo- and active arms of randomised controlled trials (RCTs) assessing analgesic treatment following third molar (M3) surgery.
Methods: A systematic search was performed in PubMed, Embase, Scopus, Web of Science and the Cochrane Central Register of Controlled Trials. Eligible studies had to report the number of patients experiencing at least one drug-related AE (patients with AE ≥ 1) separately for the active and placebo arms. The proportion of patients with AE ≥ 1 and drug-related dropouts were pooled, and risk differences (RDs) between patients in the placebo- and active arm were calculated.
Results: In 50 independent RCTs of 47 identified articles, the pooled rates of patients with AE ≥ 1 were 22.8% in the placebo arm and 20.6% in the active arm. The pooled rates of drug-related dropout were 0.24% in the placebo arm and 0.08% in the active arm. There were no significant RDs in patients with AE ≥ 1 and drug-related dropouts.
Conclusion: These results show that patients in the placebo arm reported AEs to the same extent as patients receiving active treatment, suggesting that most AEs in analgesic medication following M3 surgery may be attributed to the nocebo phenomenon. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
analgesics |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
long term adverse effects |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
nocebo effect |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
oral surgery |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
pain |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
third molar |
| 書誌情報 |
en : Journal of Oral Rehabilitation
巻 50,
号 4,
p. 332-342,
発行日 2023-01-17
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13652842 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11628445 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00704042 |
| 出版者 |
|
|
出版者 |
John Wiley & Sons |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| EID |
|
|
識別子 |
393554 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
joor_50_4_332.pdf (779 KB)
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