| Item type |
文献 / Documents(1) |
| 公開日 |
2023-08-22 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1093/ehjopen/oeac057 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1093/ehjopen/oeac057 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Effects of high-absorption curcumin for the prevention of hypertensive heart disease : a double-blind, placebo-controlled, randomized clinical study |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
High-absorption curcumin reduces BNP in hypertensive heart disease |
|
言語 |
en |
| 著者 |
船本, 雅文
スナガワ, ヨウイチ
カタナサカ, ヤスフミ
カトウ, トオル
フナダ, ジュンイチ
アジロ, ヨウイチ
コミヤマ, マキ
アカオ, マサハル
ヤソダ, アキヒロ
ヤマカゲ, ハジメ
サトウ アサハラ, ノリコ
ワダ, ヒロミチ
池田, 康将
モリモト, タツヤ
ハセガワ, コウジ
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Aims
Hypertension is a strong risk factor for heart failure with preserved ejection fraction. Curcumin has p300-specific histone acetyltransferase inhibitory activity, suppresses cardiomyocyte hypertrophy and fibrosis, and significantly reduces myocardial brain natriuretic peptide (BNP) expression without altering blood pressure in a rat model of hypertensive heart disease. This double-blind, placebo-controlled, randomized study, for the first time, aimed to examine the efficacy of a high-absorption curcumin for the prevention of hypertensive heart disease in humans.
Methods and results
Patients exhibiting initial signs of hypertensive heart disease with left ventricular ejection fraction ≥60% and stable blood pressure <140/90 mmHg orally took a double-blinded capsule (either a 90 mg curcumin capsule or placebo) twice daily for 24 weeks. The primary endpoint was per cent changes in left ventricular diastolic function (E/E′) from baseline to 6 months after administration. The secondary endpoint was the per cent change in plasma BNP levels. The E/E′ ratio per cent change from baseline to 6 months after administration was similar between the placebo (n = 69) and the curcumin (n = 73) groups. The per cent change in plasma BNP levels was significantly lower in the curcumin group than in the placebo group. In patients <65 years, BNP per cent changes were significantly lower in the curcumin group than in the placebo group, but similar between groups in ≥65 years (<65 vs. ≥65 years: P for interaction = 0.011).
Conclusions
A high-absorption curcumin agent did not affect the E/E′ ratio, rather it significantly inhibited the increase in plasma BNP levels in patients with initial signs of hypertensive heart disease. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Curcumin |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Hypertension |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Cardiac hypertrophy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Diastolic dysfunction |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
B-type natriuretic peptide |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Prevention |
| 書誌情報 |
en : European Heart Journal Open
巻 2,
号 5,
p. oeac057,
発行日 2022-09-10
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
27524191 |
| 出版者 |
|
|
出版者 |
Oxford University Press |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
European Society of Cardiology |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
| EID |
|
|
識別子 |
392443 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
ehjo_2_5_oeac057.pdf (779 KB)
.png)
