| Item type |
文献 / Documents(1) |
| 公開日 |
2024-03-15 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
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|
関連識別子 |
https://doi.org/10.3390/microorganisms10122495 |
|
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関連名称 |
10.3390/microorganisms10122495 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Effects of Helicobacter pylori and Nitrate-Reducing Bacteria Coculture on Cells |
| 著者 |
オジマ, ヒナコ
クラオカ, サキコ
オカノウエ, ショウタロウ
オカダ, ヒロユキ
ゴトウ, カズヨシ
マツシタ, オサム
渡辺, 朱理
ヨコタ, ケンジ
|
| 抄録 |
|
|
内容記述 |
Helicobacter pylori infection is an important risk factor for developing gastric cancer. However, only a few H. pylori-infected people develop gastric cancer. Thus, other risk factors aside from H. pylori infection may be involved in gastric cancer development. This study aimed to investigate whether the nitrate-reducing bacteria isolated from patients with atrophic gastritis caused by H. pylori infection are risk factors for developing atrophic gastritis and gastric neoplasia. Nitrate-reducing bacteria were isolated from patients with atrophic gastritis caused by H. pylori infection. Among the isolated bacteria, Actinomyces oris, Actinomyces odontolyticus, Rothia dentocariosa, and Rothia mucilaginosa were used in the subsequent experiments. Cytokine inducibility was evaluated in monocytic cells, and mitogen-activated protein kinase (MAPK) activity and cell cycle were assessed in the gastric epithelial cells. The cytotoxicities and neutrophil-inducing abilities of the Actinomyces and Rothia species were enhanced when cocultured with H. pylori. Th1/Th2-related cytokines were also expressed, but their expression levels differed depending on the bacterial species. Moreover, H. pylori and Actinomyces activated MAPK (ERK and p38) and affected cell cycle progression. Some nitrate-reducing bacteria cocultured with H. pylori may promote inflammation and atrophy by inducing cytokine production. In addition, the MAPK activation and cell cycle progression caused by these bacteria can contribute to gastric cancer development. |
| キーワード |
|
|
主題 |
Helicobacter pylori |
| キーワード |
|
|
主題 |
nitrate-reducing bacteria |
| キーワード |
|
|
主題 |
IL-8 |
| キーワード |
|
|
主題 |
TNF-α |
| キーワード |
|
|
主題 |
cell cycle |
| 書誌情報 |
en : Microorganisms
巻 10,
号 12,
p. 2495,
発行日 2022-12-16
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
20762607 |
| 出版者 |
|
|
出版者 |
MDPI |
| 権利情報 |
|
|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
395475 |
| 言語 |
|
|
言語 |
eng |
microorganisms_10_12_2495.pdf (716 KB)
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