| Item type |
文献 / Documents(1) |
| 公開日 |
2024-05-21 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1074/jbc.M116.734624 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1074/jbc.M116.734624 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Dual Roles of Group IID Phospholipase A2 in Inflammation and Cancer |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
sPLA2- IID, an Immunosuppressive sPLA2 |
|
言語 |
en |
| 著者 |
ミキ, ヨシミ
キドグチ, ユウ
サトウ, マリコ
タケトミ, ヨシタカ
タヤ, チョウジ
ムラマツ, カズアキ
Gelb, Michael H.
山本, 圭
ムラカミ, マコト
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Phospholipase A2 enzymes have long been implicated in the promotion of inflammation by mobilizing pro-inflammatory lipid mediators, yet recent evidence suggests that they also contribute to anti-inflammatory or pro-resolving programs. Group IID-secreted phospholipase A2 (sPLA2-IID) is abundantly expressed in dendritic cells in lymphoid tissues and resolves the Th1 immune response by controlling the steady-state levels of anti-inflammatory lipids such as docosahexaenoic acid and its metabolites. Here, we show that psoriasis and contact dermatitis were exacerbated in Pla2g2d-null mice, whereas they were ameliorated in Pla2g2d-overexpressing transgenic mice, relative to littermate wild-type mice. These phenotypes were associated with concomitant alterations in the tissue levels of ω3 polyunsaturated fatty acid (PUFA) metabolites, which had the capacity to reduce the expression of pro-inflammatory and Th1/Th17- type cytokines in dendritic cells or lymph node cells. In the context of cancer, however, Pla2g2d deficiency resulted in marked attenuation of skin carcinogenesis, likely because of the augmented anti-tumor immunity. Altogether, these results underscore a general role of sPLA2-IID as an immunosuppressive sPLA2 that allows the microenvironmental lipid balance toward an anti-inflammatory state, exerting beneficial or detrimental impact depending upon distinct pathophysiological contexts in inflammation and cancer. |
|
言語 |
en |
| 書誌情報 |
en : Journal of Biological Chemistry
巻 291,
号 30,
p. 15588-15601,
発行日 2016-05-21
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
00219258 |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1083351X |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA1202441X |
| 出版者 |
|
|
出版者 |
American Society for Biochemistry and Molecular Biology |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Elsevier |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is an open access article under the CC BY license. |
| EID |
|
|
識別子 |
313726 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jbc_291_30_15588.pdf (4.06 MB)
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