| Item type |
文献 / Documents(1) |
| 公開日 |
2024-05-07 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
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|
関連識別子 |
https://doi.org/10.3757/jser.82.26 |
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|
関連名称 |
10.3757/jser.82.26 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
カルバマゼピン中毒により下眼瞼向き眼振を認めた薬剤性めまい症例 |
| タイトル別表記 |
|
|
その他のタイトル |
A Case of Downbeat Nystagmus Induced by Carbamazepine Intoxication |
| 著者 |
松田, 和徳
佐藤, 豪
福田, 潤弥
高岡, 奨
戸村, 美紀
松岡, 百百世
東, 貴弘
北村, 嘉章
今井, 貴夫
武田, 憲昭
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| 抄録 |
|
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内容記述 |
We report the case of a 33-year-old man who presented with disequilibrium and downbeat nystagmus. Balance testing showed failure of visual suppression of caloric nystagmus with insufficient optokinetic nystagmus responses, suggesting central vestibular dysfunction. However, MRI showed no lesions in the brain, including in the cerebellum. The patient had been diagnosed previously as having epilepsy, and the convulsions had remained under control for more than 10 years with a maintenance dose of carbamazepine (900mg/day). Blood tests revealed a serum level of carbamazepine of 10.7mEq/l, which was over the therapeutic range (4.0-10.0mEq/l). Therefore, his carbamazepine dose was reduced, and with a reduction of the dose to 600mg/day, his disequilibrium and downbeat nystagmus gradually disappeared, along with a decrease in return of the serum level of carbamazepine to the therapeutic range. Therefore, we diagnosed the disequilibrium with downbeat nystagmus in this patient as having been caused by carbamazepine intoxication. Although carbamazepine is metabolized by CYP3A4 in the liver, elevated levels of the drug have been reported in cases of renal failure. As he also suffered from polycystic kidneys, we consider that the progressive renal dysfunction in our patient could have precipitated the carbamazepine intoxication. |
| キーワード |
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|
主題 |
carbamazepine |
| キーワード |
|
|
主題 |
downbeat nystagmus |
| キーワード |
|
|
主題 |
carbamazepine intoxication |
| 書誌情報 |
en : Equilibrium Research
巻 82,
号 1,
p. 26-33,
発行日 2023-02-28
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1882577X |
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03855716 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00001485 |
| 出版者 |
|
|
出版者 |
日本めまい平衡医学会 |
| EID |
|
|
識別子 |
395908 |
| 言語 |
|
|
言語 |
jpn |
er_82_1_26.pdf (1.66 MB)
