| Item type |
文献 / Documents(1) |
| 公開日 |
2024-05-21 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.5966/sctm.2015-0353 |
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|
言語 |
ja |
|
|
関連名称 |
10.5966/sctm.2015-0353 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Multifaceted Therapeutic Benefits of Factors Derived From Dental Pulp Stem Cells for Mouse Liver Fibrosis |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
Dental Pulp Stem Cell Factors for Treating LF |
|
言語 |
en |
| 著者 |
ヒラタ, マリナ
イシガミ, マサトシ
マツシタ, ヨシヒロ
イトウ, タカノリ
ハットリ, ヒサシ
ヒビ, ヒデハル
ゴトウ, ヒデミ
ウエダ, ミノル
山本, 朗仁
|
| 抄録 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Chronic liver injury from various causes often results in liver fibrosis (LF). Although the liver possesses endogenous tissue-repairing activities, these can be overcome by sustained inflammation and excessive fibrotic scar formation. Advanced LF leads to irreversible cirrhosis and subsequent liver failure and/or hepatic cancer. Here, using the mouse carbon tetrachloride (CCl4)-induced LF model, we showed that a single intravenous administration of stem cells derived from human exfoliated deciduous teeth (SHEDs) or of SHED-derived serum-free conditioned medium (SHED-CM) resulted in fibrotic scar resolution. SHED-CM suppressed the gene expression of proinflammatory mediators, such as TNF-α, IL-1β, and iNOS, and eliminated activated hepatic stellate cells by inducing their apoptosis, but protected parenchymal hepatocytes from undergoing apoptosis. In addition, SHED-CM induced tissue-repairing macrophages that expressed high levels of the profibrinolytic factor, matrix metalloproteinase 13. Furthermore, SHED-CM suppressed the CCl4-induced apoptosis of primary cultured hepatocytes. SHED-CM contained a high level of hepatocyte growth factor (HGF). Notably, HGF-depleted SHED-CM (dHGF-CM) did not suppress the proinflammatory response or resolve fibrotic scarring. Furthermore, SHED-CM, but not dHGF-CM, inhibited CCl4-induced hepatocyte apoptosis. These results suggest that HGF plays a central role in the SHED-CM-mediated resolution of LF. Taken together, our findings suggest that SHED-CM provides multifaceted therapeutic benefits for the treatment of LF. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Liver fibrosis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Dental pulp stem cells |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Conditioned media |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Inflammation |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Macrophages |
| 書誌情報 |
en : STEM CELLS Translational Medicine
巻 5,
号 10,
p. 1416-1424,
発行日 2016-06-08
|
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
21576580 |
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
21576564 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12597700 |
| 出版者 |
|
|
出版者 |
AlphaMed Press |
|
言語 |
en |
| 出版者 |
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|
出版者 |
Oxford University Press |
|
言語 |
en |
| 権利情報 |
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|
言語 |
en |
|
権利情報 |
STEM CELLS Translational Medicine® is a monthly, peer-reviewed, online only, open access journal. |
| EID |
|
|
識別子 |
321509 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
sctm_5_10_1416.pdf (2.04 MB)
