| Item type |
文献 / Documents(1) |
| 公開日 |
2024-07-12 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1210/jendso/bvab150 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1210/jendso/bvab150 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Identification and Functional Characterization of a Novel Androgen Receptor Coregulator, EAP1 |
|
言語 |
en |
| 著者 |
ヨコヤマ, アツシ
コウケツ, タクミ
オツボ, ユウリ
ノロ, エリカ
沢津橋, 俊
シマ, ヒロキ
サトウ, イクロウ
カワムラ, サダフミ
スズキ, タカシ
イガラシ, カズヒコ
スガワラ, アキラ
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The androgen receptor (AR) plays an essential role in the development of prostate cancer, and androgen-deprivation therapy is used as a first-line treatment for prostate cancer. However, under androgen-deprivation therapy, castration-resistant prostate cancer inevitably arises, suggesting that the interacting transcriptional coregulators of AR are promising targets for developing novel therapeutics. In this study, we used novel proteomic techniques to evaluate the AR interactome, including biochemically labile binding proteins, which might go undetected by conventional purification methods. Using rapid immunoprecipitation mass spectrometry of endogenous proteins, we identified enhanced at puberty 1 (EAP1) as a novel AR coregulator, whereas its interaction with AR could not be detected under standard biochemical conditions. EAP1 enhanced the transcriptional activity of AR via the E3 ubiquitin ligase activity, and its ubiquitination substrate proteins included AR and HDAC1. Furthermore, in prostate cancer specimens, EAP1 expression was significantly correlated with AR expression as well as a poor prognosis of prostate cancer. Together, these results suggest that EAP1 is a novel AR coregulator that promotes AR activity and potentially plays a role in prostate cancer progression. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
AR |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
androgen |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
nuclear receptor |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
coactivator |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
EAP1 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
IRF2BPL |
| 書誌情報 |
en : Journal of the Endocrine Society
巻 5,
号 11,
p. bvab150,
発行日 2021-09-13
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
24721972 |
| 出版者 |
|
|
出版者 |
Endocrine Society |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Oxford University Press |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
| EID |
|
|
識別子 |
401569 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jes_5_11_bvab150.pdf (873 KB)
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