| Item type |
文献 / Documents(1) |
| 公開日 |
2025-02-06 |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.jphs.2025.01.003 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1016/j.jphs.2025.01.003 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Goreisan suppresses cardiac remodeling and dysfunction in a new mouse model with diabetic cardiomyopathy |
|
言語 |
en |
| 著者 |
船本, 雅文
Hirose, Shunji
Yamamoto, Mizuho
Ly-Nguyen, Hai Du
今西, 正樹
Ebi, Fuka
Ito, Mai
大南, 博和
土屋, 浩一郎
池田, 康将
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: The global increase in diabetes, driven by aging populations and lifestyle changes, has led to an increase in the incidence of diabetic cardiomyopathy (DCM). DCM is characterized by metabolic abnormalities, oxidative stress, and inflammation, leading to cardiac remodeling and dysfunction. Goreisan (GRS), a traditional Japanese Kampo medicine, is commonly used to treat fluid control such as edema, due to its diuretic effect. In this study, we examined the effects of GRS on DCM.
Methods: We first established a new mouse model of DCM and then evaluated the effects of GRS on DCM using a recently developed model.
Results: The DCM mouse model developed cardiac hypertrophy, fibrosis, and dysfunction by nine weeks, which was ameliorated by GRS administration. GRS suppressed apoptosis and protein degradation by inhibiting Akt dephosphorylation and oxidative stress in DCM mice. In contrast, no differences in inflammatory cytokine levels were observed, regardless of GRS administration.
Conclusion: GRS has potential efficacy in preventing DCM onset and development. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Kampo medicine |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Diabetic cardiomyopathy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Goreisan |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Apoptosis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Oxidative stress |
| 書誌情報 |
en : Journal of Pharmacological Sciences
巻 157,
号 2,
p. 104-112,
発行日 2025-01-04
|
| 収録物ID |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
13478648 |
| 収録物ID |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
13478613 |
| 出版者 |
|
|
出版者 |
Elsevier |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Japanese Pharmacological Society |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| EID |
|
|
識別子 |
416012 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jphs_157_2_104.pdf (7.4 MB)
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