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Early changes in muscle atrophy and muscle fiber type conversion after spinal cord transection and peripheral nerve transection in rats
https://tokushima-u.repo.nii.ac.jp/records/2012658
https://tokushima-u.repo.nii.ac.jp/records/2012658b01741ef-5704-4b39-96f9-0d4cb42c565d
| 名前 / ファイル | ライセンス | アクション |
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jner_10_46.pdf (2 MB)
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CC BY 2.0
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||||
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| 公開日 | 2025-03-11 | |||||||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1186/1743-0003-10-46 | |||||||||||||||||||||||||
| 関連名称 | 10.1186/1743-0003-10-46 | |||||||||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||
| タイトル | Early changes in muscle atrophy and muscle fiber type conversion after spinal cord transection and peripheral nerve transection in rats | |||||||||||||||||||||||||
| 著者 |
東野, 恒作
× 東野, 恒作× 松浦, 哲也
WEKO
1158
× Suganuma, Katsuyoshi
× 油形, 公則× 西庄, 俊彦
WEKO
552
× 安井, 夏生
WEKO
1520
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| 内容記述 | Background: Spinal cord transection and peripheral nerve transection cause muscle atrophy and muscle fiber type conversion. It is still unknown how spinal cord transection and peripheral nerve transection each affect the differentiation of muscle fiber type conversion mechanism and muscle atrophy. The aim of our study was to evaluate the difference of muscle weight change, muscle fiber type conversion, and Peroxisome proliferator-activated receptor-γ coactivatior-1α (PGC-1α) expression brought about by spinal cord transection and by peripheral nerve transection. Methods: Twenty-four Wistar rats underwent surgery, the control rats underwent a laminectomy; the spinal cord injury group underwent a spinal cord transection; the denervation group underwent a sciatic nerve transection. The rats were harvested of the soleus muscle and the TA muscle at 0 week, 1 week and 2 weeks after surgery. Histological examination was assessed using hematoxylin and eosin (H&E) staining and immunofluorescent staing. Western blot was performed with 3 groups. Results: Both sciatic nerve transection and spinal cord transection caused muscle atrophy with the effect being more severe after sciatic nerve transection. Spinal cord transection caused a reduction in the expression of both sMHC protein and PGC-1α protein in the soleus muscle. On the other hand, sciatic nerve transection produced an increase in expression of sMHC protein and PGC-1α protein in the soleus muscle. The results of the expression of PGC-1α were expected in other words muscle atrophy after sciatic nerve transection is less than after spinal cord transection, however muscle atrophy after sciatic nerve transection was more severe than after spinal cord transection. Conclusion: In the conclusion, spinal cord transection diminished the expression of sMHC protein and PGC-1α protein in the soleus muscle. On the other hand, sciatic nerve transection enhanced the expression of sMHC protein and PGC-1α protein in the soleus muscle. |
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| キーワード | ||||||||||||||||||||||||||
| 主題 | Muscle atrophy | |||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||
| 主題 | Muscle fiver type conversion | |||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||
| 主題 | Spinal cord transection | |||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||
| 主題 | Peripheral nerve transection | |||||||||||||||||||||||||
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| 主題 | Rat | |||||||||||||||||||||||||
| 書誌情報 |
en : Journal of NeuroEngineering and Rehabilitation 巻 10, p. 46, 発行日 2013-05-20 |
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||||||||
| 収録物識別子 | 17430003 | |||||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||||
| 収録物識別子 | AA12051037 | |||||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||||
| 出版者 | BioMed Central | |||||||||||||||||||||||||
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| 出版者 | Springer Nature | |||||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||||
| 権利情報 | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||||||||||||||||||||||
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| 識別子 | 274212 | |||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||
