| Item type |
文献 / Documents(1) |
| 公開日 |
2025-03-19 |
| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1093/bbb/zbae079 |
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|
関連名称 |
10.1093/bbb/zbae079 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Resveratrol and piceid enhance efferocytosis by increasing the secretion of MFG-E8 in human THP-1 macrophages |
| 著者 |
Wang, Jing
Hashimoto, Yuki
Hiemori-Kondo, Miki
中本, 晶子
酒井, 徹
Ye, Wenxiu
Abe-Kanoh, Naomi
|
| 抄録 |
|
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内容記述 |
The process of apoptotic cell clearance by phagocytes, known as efferocytosis, plays an essential role in maintaining homeostasis. Defects in efferocytosis can lead to inflammatory diseases such as atherosclerosis and autoimmune disorders. Therefore, the maintenance and promotion of efferocytosis are considered crucial for preventing these diseases. In this study, we observed that resveratrol, a representative functional food ingredient, and its glycoside, piceid, promoted efferocytosis in both human THP-1 macrophages differentiated with phorbol 12-myristate 13-acetate and peritoneal macrophages from thioglycolate-elicited mice. Resveratrol and piceid significantly increased mRNA expression and protein secretion of MFG-E8 in THP-1 macrophages. Furthermore, the activation of efferocytosis and the increment in MFG-E8 protein secretion caused by resveratrol or piceid treatment were canceled by MFG-E8 knockdown in THP-1 macrophages. In conclusion, we have demonstrated for the first time that resveratrol and piceid promote efferocytosis through the upregulation of MFG-E8 excretion in human THP-1 macrophages. |
| キーワード |
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|
主題 |
macrophage |
| キーワード |
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|
主題 |
efferocytosis |
| キーワード |
|
|
主題 |
resveratrol |
| キーワード |
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|
主題 |
anti-inflammation |
| キーワード |
|
|
主題 |
MFG-E8 |
| 書誌情報 |
en : Bioscience, Biotechnology, and Biochemistry
巻 88,
号 9,
p. 1090-1101,
発行日 2024-06-03
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| 収録物ID |
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収録物識別子タイプ |
EISSN |
|
収録物識別子 |
13476947 |
| 収録物ID |
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|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
09168451 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10824164 |
| 出版者 |
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|
出版者 |
Japan Society for Bioscience, Biotechnology, and Agrochemistry |
| 出版者 |
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|
出版者 |
Oxford University Press |
| 権利情報 |
|
|
権利情報 |
This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| EID |
|
|
識別子 |
411500 |
| 言語 |
|
|
言語 |
eng |
bbb_88_9_1090.pdf (939 KB)
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