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Enzymatic and synthetic regulation of polypeptide folding
https://tokushima-u.repo.nii.ac.jp/records/2012794
https://tokushima-u.repo.nii.ac.jp/records/2012794be1449bc-0707-42bd-80fe-267fa9921023
| 名前 / ファイル | ライセンス | アクション |
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cs_15_7_2282.pdf (2 MB)
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| アイテムタイプ | 文献 / Documents(1) | |||||||||||||||
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| 公開日 | 2025-03-14 | |||||||||||||||
| アクセス権 | ||||||||||||||||
| アクセス権 | open access | |||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| 出版社版DOI | ||||||||||||||||
| 関連識別子 | https://doi.org/10.1039/d3sc05781j | |||||||||||||||
| 関連名称 | 10.1039/d3sc05781j | |||||||||||||||
| 出版タイプ | ||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Enzymatic and synthetic regulation of polypeptide folding | |||||||||||||||
| 著者 |
Muraoka, Takahiro
× Muraoka, Takahiro
× Okumura, Masaki
× 齋尾, 智英
WEKO
1188
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| 抄録 | ||||||||||||||||
| 内容記述 | Proper folding is essential for the biological functions of all proteins. The folding process is intrinsically error-prone, and the misfolding of a polypeptide chain can cause the formation of toxic aggregates related to pathological outcomes such as neurodegenerative disease and diabetes. Chaperones and some enzymes are involved in the cellular proteostasis systems that assist polypeptide folding to diminish the risk of aggregation. Elucidating the molecular mechanisms of chaperones and related enzymes is important for understanding proteostasis systems and protein misfolding- and aggregation-related pathophysiology. Furthermore, mechanistic studies of chaperones and related enzymes provide important clues to designing chemical mimics, or chemical chaperones, that are potentially useful for recovering proteostasis activities as therapeutic approaches for treating and preventing protein misfolding-related diseases. In this Perspective, we provide a comprehensive overview of the latest understanding of the folding-promotion mechanisms by chaperones and oxidoreductases and recent progress in the development of chemical mimics that possess activities comparable to enzymes, followed by a discussion of future directions. | |||||||||||||||
| 書誌情報 |
en : Chemical Science 巻 15, 号 7, p. 2282-2299, 発行日 2024-01-26 |
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| 収録物ID | ||||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||||
| 収録物識別子 | 20416539 | |||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | The Royal Society of Chemistry | |||||||||||||||
| 権利情報 | ||||||||||||||||
| 権利情報 | This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. | |||||||||||||||
| EID | ||||||||||||||||
| 識別子 | 412432 | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
