| Item type |
文献 / Documents(1) |
| 公開日 |
2024-01-01 |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.3390/pharmaceutics16101271 |
|
|
関連名称 |
10.3390/pharmaceutics16101271 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
A Stealthiness Evaluation of Main Chain Carboxybetaine Polymer Modified into Liposome |
| 著者 |
Najmina, Mazaya
Kobayashi, Shingo
Shimazui, Rena
髙田, 春風
Shibata, Mayuka
Ishibashi, Kenta
Kamizawa, Hiroshi
Kishimura, Akihiro
Shiota, Yoshihito
Ida, Daichi
清水, 太郎
石田, 竜弘
Katayama, Yoshiki
Tanaka, Masaru
Mori, Takeshi
|
| 抄録 |
|
|
内容記述 |
Background: Acrylamide polymers with zwitterionic carboxybetaine (CB) side groups have attracted attention as stealth polymers that do not induce antibodies when conjugated to proteins. However, they induce antibodies when modified onto liposomes. We hypothesized that antibodies are produced against polymer backbones rather than CB side groups. Objectives: In this study, we designed and synthesized a polymer employing CB in its main chain, poly(N-acetic acid-N-methyl-propyleneimine) (PAMPI), and evaluated the blood retention of PAMPI-modified liposomes in mice. Results: The non-fouling nature of PAMPI-modified liposomes estimated from serum protein adsorption was found to be not inferior to PCB- and PEG-modified liposomes. However, to our surprise, the PAMPI-modified liposomes showed an instantaneous clearance less than 1 h post-injection, comparable to the naked liposomes. Conclusions: The extent of the blood retention of polymer-modified liposomes cannot be predicted by their susceptibility to serum protein adsorption and semi-flexible conformation. |
| キーワード |
|
|
主題 |
zwitterionic polymer |
| キーワード |
|
|
主題 |
carboxybetaine |
| キーワード |
|
|
主題 |
non-fouling polymer |
| キーワード |
|
|
主題 |
liposome |
| 書誌情報 |
en : Pharmaceutics
巻 16,
号 10,
p. 1271,
発行日 2024-09-28
|
| 収録物ID |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
19994923 |
| 出版者 |
|
|
出版者 |
MDPI |
| 権利情報 |
|
|
権利情報 |
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
414762 |
| 言語 |
|
|
言語 |
eng |
pharm_16_10_1271.pdf (2.9 MB)
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